Details

Autor(en) / Beteiligte

• Banoei, Mohammad Mehdi
• Chaleshtori, Morteza Hashemzadeh
• Sanati, Mohammah Hossein
• Panahi, Mehdi Shafa Sharait
• Majidizadeh, Tayebeh
• Rostami, Maryam
• Manshadi, Massoumeh Dehghan
• Golalipour, Masoud

Titel

Diversity and relationship between Iranian ethnic groups: Human dopamine transporter gene (DAT1) VNTR genotyping

Ist Teil von

• American journal of human biology, 2007-11, Vol.19 (6), p.821-826

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• The 40‐bp VNTR polymorphism in the 3′ untranslated region of the human DAT1 (dopamine transporter 1) was analyzed in the Iranian ethnic groups in order to examine the influence of geographical and linguistic affiliation on the genetic affinities among the Iranian population. A total of 449 subjects belonging to nine ethnic groups from the Iranian population were included in the study. The screening of 898 chromosomes showed five alleles (6, 7, 8, 9, 10, and 11), of which allele 10 revealed the highest frequency in most regions. Allele 8 was predominant in one ethnicity and occurred more frequently in the center of Iran. This study shows that the DAT1 distribution in Iran has a different pattern from those in other studies, which can contribute to an understanding of differentiation and diversity of Iranian ethnic groups. This polymorphism could represent the genetic diversity among the various ethnic groups of Iran. Am. J. Hum. Biol., 2007. © 2007 Wiley‐Liss, Inc.