Details

Autor(en) / Beteiligte

• Abboud, Elizabeth R
• Coffelt, Seth B
• Figueroa, Yanira G
• Zwezdaryk, Kevin J
• Nelson, Anne B
• Sullivan, Deborah E
• Morris, Cindy B
• Tang, Yan
• Beckman, Barbara S
• Scandurro, Aline B

Titel

Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells

Ist Teil von

• International journal of oncology, 2007-01, Vol.30 (1), p.113-122

Ort / Verlag

Greece

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Based on cDNA microarray results, integrin-linked kinase (ILK) emerged as an interesting candidate in hypoxia-mediated survival mechanisms employed by cancer cells. This notion was confirmed here by the following observations: the 5' promoter region of the ilk gene contains hypoxia responsive elements (HRE) that bind hypoxia-inducible factor (HIF) transcription factor complexes and drive HRE-luciferase gene expression in reporter assays; ILK protein and kinase activity are induced following hypoxia; downstream targets of ILK signaling are induced following hypoxia treatment; inhibition of ILK leads to increased apoptosis; and HIF and ILK are co-localized within human cancer tissues. The identification of ILK as a player in hypoxia survival signaling employed by cancer cells further validates ILK as a unique target for cancer therapy.