Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Various synthetic analogues of Oenostacin, a naturally occurring plant lead compound, have been synthesized. Some of the analogues possessed potent antibacterial activities against
Staphylococcus epidermidis and
Staphylococcus aureus. However, none of these was as active as Oenostacin.
Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is,
22,
23 and
42, possessed potent antibacterial activities against
Staphylococcus epidermidis and
Staphylococcus aureus having EC
50 ranging from 0.49 to 0.67
μM as compared to Oenostacin (EC
50
=
0.12
μM).