Details

Autor(en) / Beteiligte

• Uberti, Daniela
• Bianchi, Irene
• Olivari, Luca
• Ferrari-Toninelli, Giulia
• Bonini, Sara A
• Memo, Maurizio

Titel

Dopaminergic agonists: possible neurorescue drugs endowed with independent and synergistic multisites of action

Ist Teil von

• Neurochemical research, 2007-10, Vol.32 (10), p.1726-1729

Ort / Verlag

United States: Springer Nature B.V

Erscheinungsjahr

2007

Quelle

SpringerLink

Beschreibungen/Notizen

• Dopaminergic agonists have been usually used as adjunctive therapy for the cure of Parkinson's disease (PD). It is generally believed that treatment with these drugs is symptomatic rather then curative and does not stop or delay the progression of neuronal degeneration. However, several DA agonists of the DA D2-receptor family (including D2, D3 and D4-subtypes) have recently been shown to possess neuroprotective properties in different in vitro and in vivo experimental PD models. Here we summarize some recent data from our and other groups underlining the wide pharmacological spectrum of DA agonists currently used for treating PD patients. In particular, the mechanism of action of different DA agonists does not appear to be restricted to the stimulation of selective DA receptor subtypes being these drugs endowed with intrinsic, independent, and peculiar antioxidant effects. This activity may represent an additional pharmacological property contributing to their clinical efficacy in PD.