Details

Autor(en) / Beteiligte

• Nishioka, Takeshi
• Homma, Akihiro
• Furuta, Yasushi
• Aoyama, Hidefumi
• Suzuki, Fumiyuki
• Ohmori, Keiichi
• Asano, Takeshi
• Yoshida, Daisuke
• Shirato, Hiroki
• Fukuda, Satoshi

Titel

A Novel Approach to Advanced Carcinoma of the Tongue: Cases Successfully Treated with Combination of Superselective Intra-Arterial Chemotherapy and External/High-Dose-Rate Interstitial Radiotherapy

Ist Teil von

• Japanese journal of clinical oncology, 2006-12, Vol.36 (12), p.822-826

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2006

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Objective This study sought to evaluate the efficacy and safety of a novel treatment regimen, intra-arterial cisplatin infusion plus external/high-dose-rate radiotherapy. Methods Superselective intra-arterial infusion of cisplatin (100–120 mg) was performed concomitantly with external radiotherapy in four patients with locally advanced carcinoma of the tongue. A high-dose-rate brachytherapy boost was performed after combination therapy in all patients. Brachytherapy was performed after external radiotherapy, and the treatment schedule was twice daily, with a fraction of 600 cGy up to a total of 30–48 Gy. Results All patients completed the therapy as scheduled. There were no vascular or neurological complications. Grade III acute radiation mucositis developed in all patients but this did not necessitate a treatment break. With a mean follow-up period of 35 months, loco-regional control was obtained for all patients. Conclusions The combination of weekly administration of intra-arterial cisplatin plus external/high-dose-rate radiotherapy seems effective for advanced carcinoma of the tongue.