Epilepsia (Copenhagen), 2006-12, Vol.47 (12), p.2202-2205
2006
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- Autor(en) / Beteiligte
- Titel
- The Risk of Lower Mental Outcome in Infantile Spasms Increases after Three Weeks of Hypsarrhythmia Duration
- Ist Teil von
- Epilepsia (Copenhagen), 2006-12, Vol.47 (12), p.2202-2205
- Ort / Verlag
- Malden, USA: Blackwell Publishing Inc
- Erscheinungsjahr
- 2006
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- To assess the correlation between hypsarrhythmia duration and mental outcome in infantile spasms (IS) the medical records of 48 infants with IS were reviewed retrospectively and psychological assessments undertaken at follow‐up at the age of 3 to 13 years. We found 18 (38%) cryptogenic IS cases with typical hypsarrhythmia and 30 symptomatic with modified hypsarrhythmia—further classified into 15 cases as multifocal, 10 as pseudoperiodic and 5 as unilateral hypsarrhythmia. A short treatment lag (one to two weeks) occurred in 25, three to four weeks in 10 cases. Spasms ceased within one month after treatment in 23 infants. At follow‐up 15 children had normal mental outcome (borderline included). A correlation between hypsarrhythmia duration longer than three weeks and lower mental outcome was found using the logistic regression model. The duration of hypsarrhythmia represents a sensitive prognostic parameter in IS; the risk of mental retardation increases after three weeks of hypsarrhythmia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0013-9580eISSN: 1528-1167DOI: 10.1111/j.1528-1167.2006.00888.xTitel-ID: cdi_proquest_miscellaneous_68280199
- Format
- –
- Schlagworte
- Age of Onset, Anticonvulsants - therapeutic use, Biological and medical sciences, Child, Child, Preschool, Children, Duration of hypsarrhythmia, Electroencephalography - statistics & numerical data, Female, Functional Laterality - physiology, Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy, Hormones. Endocrine system, Humans, Infant, Infantile spasms, Intellectual Disability - diagnosis, Intellectual Disability - etiology, Intellectual Disability - prevention & control, Intelligence Tests, Logistic Models, Male, Medical sciences, Mental outcome, Metabolic diseases, Metals (hemochromatosis...), Nervous system (semeiology, syndromes), Neurology, Neuropsychological Tests, Other metabolic disorders, Pharmacology. Drug treatments, Prognosis, Retrospective Studies, Risk Factors, Spasms, Infantile - complications, Spasms, Infantile - diagnosis, Spasms, Infantile - drug therapy, Time Factors