FEMS immunology and medical microbiology, 2007-10, Vol.51 (1), p.43-57
2007
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- Autor(en) / Beteiligte
- Titel
- The transcriptional profile of Paracoccidioides brasiliensis yeast cells is influenced by human plasma
- Ist Teil von
- FEMS immunology and medical microbiology, 2007-10, Vol.51 (1), p.43-57
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2007
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Abstract Paracoccidioides brasiliensis causes infection through host inhalation of airborne propagules of the mycelial phase of the fungus, which reach the lungs, and then disseminate to virtually all parts of the human body. Here we describe the identification of differentially expressed genes in P. brasiliensis yeast cells, by analyzing cDNA populations from the fungus treated with human plasma, mimicking superficial infection sites with inflammation. Our analysis identified transcripts that are differentially represented. The transcripts upregulated in yeast cells during incubation in human plasma were predominantly related to fatty acid degradation, protein synthesis, sensing of osmolarity changes, cell wall remodeling and cell defense. The expression pattern of genes was independently confirmed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0928-8244eISSN: 1574-695X, 2049-632XDOI: 10.1111/j.1574-695X.2007.00277.xTitel-ID: cdi_proquest_miscellaneous_68273844
- Format
- –
- Schlagworte
- Airborne infection, Biodegradation, Biological and medical sciences, Blood plasma, Cell walls, Fatty acids, Fundamental and applied biological sciences. Psychology, Fungi, Gene expression, Gene Expression Profiling, Gene Expression Regulation, Fungal, Genes, Glutamate-Ammonia Ligase - genetics, human plasma, Humans, Inhalation, Melanins - biosynthesis, Microbiology, Mimicry, Miscellaneous, Mycelia, Mycology, Osmolarity, Paracoccidioides - genetics, Paracoccidioides - metabolism, Paracoccidioides brasiliensis, Plasma - physiology, Propagules, Protein biosynthesis, Protein synthesis, Respiration, Serine Endopeptidases - genetics, Signal Transduction, Sodium Dodecyl Sulfate - pharmacology, Transcription, Yeast, Yeasts