Details

Autor(en) / Beteiligte

• Rathinasamy, Suresh
• Karki, Subhas Somalingappa
• Bhattacharya, Shiladitya
• Manikandan, Lakshmanan
• Prabakaran, Senthilkumar G.
• Gupta, Malaya
• Mazumder, Upal Kanti

Titel

Synthesis and anticancer activity of certain mononuclear Ru (II) Complexes

Ist Teil von

• Journal of enzyme inhibition and medicinal chemistry, 2006-10, Vol.21 (5), p.501-507

Ort / Verlag

England: Informa UK Ltd

Erscheinungsjahr

2006

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Bis(1,10-phenanthroline/2,2′-bipyridine) ruthenium(II)complexes containing TCP, TTZ OPBI, and BTSC ligands (where, TCP = 1-thiocarbamoyl-3,5-diphenyl-2-pyrazoline,TTZ = 2-(3,5-diphenyl-4,5-dihydropyrazol-1-yl)-4-phenylthiazole, OPBI = 2-hydroxyphenyl benzimidazole and BTSC = benzoin thiosemicarbazone) have been prepared and characterized. The spectral data suggested that the ligands were coordinated with the metal through nitrogen, sulfur and oxygen atoms. The target complexes were tested in vivo for anticancer activity against transplantable murine tumor cell line, Ehrlich's Ascitic Carcinoma (EAC). All these complexes increased the life span of the EAC-bearing mice, decreased their tumor volume and viable ascitic cell count as well as improved Hb, RBC and WBC counts. These results suggest that the Ru(II) complexes exhibit significant antitumor activity in EAC-bearing mice. It was also observed that the ruthenium complexes protected red blood cells from 2,2′-azo-bis(2-methylpropionamidine) dihydrochloride (AAPH)- induced hemolysis. The inhibitory effect was dose-dependent at a concentration of 20-120 μg/ml.