Details

Autor(en) / Beteiligte

• Chen, Si Wei
• Wang, Wen Juan
• Li, Wei Jing
• Wang, Rui
• Li, Yu Lei
• Huang, Yan Ni
• Liang, Xin

Titel

Anxiolytic-like effect of asiaticoside in mice

Ist Teil von

• Pharmacology, biochemistry and behavior, 2006-10, Vol.85 (2), p.339-344

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• The putative anxiolytic activity of asiaticoside was examined in male mice by using a number of experimental paradigms of anxiety, with diazepam being as a positive anxiolytic control. In the elevated plus-maze test, diazepam (1 and 2 mg/kg) or asiaticoside (5 or 10 mg/kg) increased the percentage of entries into open arms and of time spent on open arms. In the light/dark test, as with 1 mg/kg diazepam, asiaticoside (10 and 20 mg/kg) increased the time spent in the light area and the movement in the light area without altering the total locomotor activity of the animals. In the hole-board test, asiaticoside at 10 mg/kg significantly increased head-dipping counts and duration as well as diazepam (0.3 mg/kg). Thus, these findings indicated that asiaticoside exhibited an anxiolytic-like effect. Further studies will be required to assess the generality of present findings to other species and behavioural paradigms.