FEMS yeast research, 2006-12, Vol.6 (8), p.1140-1148
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen
- Ist Teil von
- FEMS yeast research, 2006-12, Vol.6 (8), p.1140-1148
- Ort / Verlag
- Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
- Erscheinungsjahr
- 2006
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast[rightward arrow]pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1567-1356eISSN: 1567-1364DOI: 10.1111/j.1567-1364.2006.00097.xTitel-ID: cdi_proquest_miscellaneous_68237530
- Format
- –
- Schlagworte
- Antifungal Agents - pharmacology, Apoptosis, Apoptosis - drug effects, Candida albicans, Candida albicans - drug effects, Candida albicans - growth & development, candidiasis, Cell death, Cell Membrane - drug effects, Cell Membrane - metabolism, chemotherapy, DNA Fragmentation - drug effects, DNA, Fungal - drug effects, Fluidity, Humans, Hyphae, Lovastatin, Lovastatin - pharmacology, Membrane fluidity, Opportunist infection, Pathogens, pseudomycelium, Tumor cell lines, Tumors