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BMP‐4 and Noggin signaling modulate dorsal fin and somite development in the axolotl trunk
Developmental dynamics, 2007-09, Vol.236 (9), p.2464-2474
Epperlein, Hans H.
Vichev, Konstantin
Heidrich, Felix M.
Kurth, Thomas
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Epperlein, Hans H.
Vichev, Konstantin
Heidrich, Felix M.
Kurth, Thomas
Titel
BMP‐4 and Noggin signaling modulate dorsal fin and somite development in the axolotl trunk
Ist Teil von
Developmental dynamics, 2007-09, Vol.236 (9), p.2464-2474
Ort / Verlag
New York: Wiley‐Liss, Inc
Erscheinungsjahr
2007
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
BMP‐4, a member of the TGF‐beta superfamily of growth factors, is involved in various developmental processes. We investigated the effects of BMP‐4 and its antagonist Noggin on axolotl trunk development. Implantation of BMP‐4‐coated microbeads caused inhibition of muscle and dorsal fin formation in the vicinity of the microbeads. At some distance, myotomes developed with reduced height but increased width, which was accompanied by increased cell proliferation. These effects could be modulated by co‐implanting Noggin‐coated beads. Immunostaining of Pax7 further revealed that although the dermomyotome was absent in the vicinity of BMP‐4‐coated beads, at some distance from them, it was thicker than in controls, indicating that moderate amounts of BMP‐4 stimulate this layer of undifferentiated cells. In contrast, Noggin generally inhibited the dermomyotome, possibly indicating premature differentiation of dermomyotome cells. We conclude that BMP‐4 and Noggin are involved in the regulation of cell proliferation and differentiation during somite development. Developmental Dynamics 236:2464–2474, 2007. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1058-8388
eISSN: 1097-0177
DOI: 10.1002/dvdy.21247
Titel-ID: cdi_proquest_miscellaneous_68224784
Format
–
Schlagworte
Ambystoma
,
Ambystoma - embryology
,
Ambystoma - physiology
,
Animals
,
axolotl
,
BMP‐4
,
Bone Morphogenetic Protein 4
,
Bone Morphogenetic Proteins - physiology
,
Carrier Proteins - physiology
,
Cell Differentiation
,
cell division
,
Cell Proliferation
,
Dermis - embryology
,
dermomyotome
,
Developmental Biology - methods
,
dorsal fin
,
Extremities - physiology
,
Fishes
,
Gene Expression Regulation, Developmental
,
Models, Biological
,
Muscle Development
,
Noggin
,
Pax7
,
somite
,
Somites - metabolism
,
Xenopus
,
Xenopus Proteins
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