Journal of neuroimmunology, 2006-12, Vol.181 (1), p.145-149
2006
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- Autor(en) / Beteiligte
- Titel
- Increased serum levels of soluble CD14 indicate stable multiple sclerosis
- Ist Teil von
- Journal of neuroimmunology, 2006-12, Vol.181 (1), p.145-149
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The aim of this study was to evaluate a possible role of soluble CD14 (sCD14) in multiple sclerosis (MS). We found that sCD14 serum levels measured by ELISA were higher in MS patients compared to neurological and healthy controls. Within the MS group sCD14 levels were increased in relapsing–remitting and secondary progressive MS compared to primary progressive MS. Furthermore, sCD14 concentrations were increased during stable disease. An increased expression of sCD14 was also detected after treatment with interferon-beta. In summary, we report evidence that serum sCD14 levels are increased in MS and correlate inversely with disease activity in relapsing MS patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-5728eISSN: 1872-8421DOI: 10.1016/j.jneuroim.2006.09.002Titel-ID: cdi_proquest_miscellaneous_68213188
- Format
- –
- Schlagworte
- Adult, Disease activity, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunologic Factors - therapeutic use, Innate immunity, Interferon-beta - therapeutic use, Lipopolysaccharide Receptors - blood, Male, Middle Aged, Multiple sclerosis, Multiple Sclerosis, Chronic Progressive - blood, Multiple Sclerosis, Chronic Progressive - drug therapy, Multiple Sclerosis, Chronic Progressive - immunology, Multiple Sclerosis, Relapsing-Remitting - blood, Multiple Sclerosis, Relapsing-Remitting - drug therapy, Multiple Sclerosis, Relapsing-Remitting - immunology, Severity of Illness Index, Solubility, Soluble CD14