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Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis
International journal of cancer, 2007-10, Vol.121 (8), p.1813-1820
Ragin, Camille C. R.
Taioli, Emanuela
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ragin, Camille C. R.
Taioli, Emanuela
Titel
Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis
Ist Teil von
International journal of cancer, 2007-10, Vol.121 (8), p.1813-1820
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Human papillomavirus (HPV) has been associated with head and neck squamous cell carcinomas (HNSCC), especially of the oropharynx, with highest distribution in the tonsils. HPV infection has been associated with improved outcome, although not all the studies show consistent results. The reason for this is not clear. We reviewed all published articles and conducted a meta‐analysis on the overall relationship between HPV infection and overall survival (OS) and disease‐free survival (DFS) in HNSCC. Patients with HPV‐positive HNSCC had a lower risk of dying (meta HR: 0.85, 95% CI: 0.7–1.0), and a lower risk of recurrence (meta HR: 0.62, 95%CI: 0.5–0.8) than HPV‐negative HNSCC patients. Site‐specific analyses show that patients with HPV‐positive oropharyngeal tumours had a 28% reduced risk of death (meta HR: 0.72, 95%CI: 0.5–1.0) in comparison to patients with HPV‐negative oropharyngeal tumours. Similar observations were made for DFS (meta HR: 0.51, 95% CI: 0.4–0.7). There was no difference in OS between HPV‐positive and negative non‐oropharyngeal patients. The observed improved OS and DFS for HPV‐positive HNSCC patients is specific to the oropharynx; these tumours may have a distinct etiology from those tumours in non‐oropharyngeal sites. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.22851
Titel-ID: cdi_proquest_miscellaneous_68203765
Format
–
Schlagworte
Biological and medical sciences
,
Carcinoma, Squamous Cell - mortality
,
Carcinoma, Squamous Cell - virology
,
Disease-Free Survival
,
Global Health
,
head and neck cancer
,
Head and Neck Neoplasms - mortality
,
Head and Neck Neoplasms - virology
,
HPV
,
Human papillomavirus
,
Humans
,
Medical sciences
,
Otorhinolaryngology (head neck, general aspects and miscellaneous)
,
Otorhinolaryngology. Stomatology
,
overall survival
,
Papillomavirus Infections - complications
,
Papillomavirus Infections - epidemiology
,
Prevalence
,
Survival Analysis
,
Tumors
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