Details

Autor(en) / Beteiligte

• Sugimoto, Mitsushige
• Furuta, Takahisa
• Shirai, Naohito
• Nakamura, Akiko
• Kajimura, Masayoshi
• Sugimura, Haruhiko
• Hishida, Akira

Titel

Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects

Ist Teil von

• Journal of gastroenterology and hepatology, 2007-09, Vol.22 (9), p.1443-1449

Ort / Verlag

Melbourne, Australia: Blackwell Publishing Asia

Erscheinungsjahr

2007

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background:  Anti‐inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti‐inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the IL‐10 polymorphism, one of the representative anti‐inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan. Methods:  The IL‐10‐1082 (A/G)/‐819 (T/C)/‐592 (A/C) polymorphisms were assessed in Helicobacter pylori‐positive patients with gastritis only (n = 162), gastric ulcers (n = 110), duodenal ulcers (n = 94), or gastric cancers (n = 105), and H. pylori‐negative controls (n = 168) by allele specific primer–polymerase chain reaction methods. Results:  The carriage of IL‐10‐592 C (age and sex‐adjusted odds ratio [OR]: 1.851, 95% confidence interval [CI]: 1.018–3.380) and IL‐10‐819 C (adjusted OR: 1.868, 95%CI: 1.023–3.411) allele were associated with an increased risk for gastric cancer development, not gastric ulcer and duodenal ulcer. The IL‐10‐1082 polymorphism had no association with development of gastric cancer and peptic ulcers. The presence of the ATA/GCC haplotype of IL‐10‐1082/‐819/‐592 polymorphism significantly increased the risk of gastric cancer development (adjusted OR: 2.805, 95%CI: 1.258–6.254) compared with presence of the ATA/ATA haplotype. Conclusions:  The IL‐10‐1082/‐819/‐592 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan. The genotyping test of this anti‐inflammatory cytokine would be useful for the detection of individuals with higher risk of gastric cancer development.