Nature immunology, 2007-09, Vol.8 (9), p.984-991
2007
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Details
- Autor(en) / Beteiligte
- Titel
- MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit
- Ist Teil von
- Nature immunology, 2007-09, Vol.8 (9), p.984-991
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- NF-kappaB (Rel) transcription factors control physiological and pathological immune cell function. The scaffold proteins Bcl-10 and MALT1 couple antigen-receptor signals to the canonical NF-kappaB pathway and are pivotal in lymphomagenesis. Here we found that Bcl-10 and MALT1 differentially regulated B cell receptor-induced activation of RelA and c-Rel. Bcl-10 was essential for recruitment of the kinase IKK into lipid rafts for the activation of RelA and c-Rel, for blocking apoptosis and for inducing division after B cell receptor ligation. In contrast, MALT1 participated in survival signaling but was not involved in IKK recruitment or activation and was dispensable for RelA induction and proliferation. MALT1 selectively activated c-Rel to control a distinct subprogram. Our results provide mechanistic insights into B cell receptor-induced survival and proliferation signals and demonstrate the selective control of c-Rel in the canonical NF-kappaB pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1529-2908Titel-ID: cdi_proquest_miscellaneous_68190253
- Format
- –
- Schlagworte
- Adaptor Proteins, Signal Transducing - metabolism, Animals, Apoptosis - physiology, B-Cell CLL-Lymphoma 10 Protein, Caspases - immunology, Caspases - metabolism, Cell Division - physiology, Cell Survival - physiology, Flow Cytometry, Fluorescent Antibody Technique, Immunoblotting, Immunoprecipitation, Lymphocyte Activation - immunology, Membrane Microdomains - metabolism, Mice, Mice, Transgenic, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, Neoplasm Proteins - immunology, Neoplasm Proteins - metabolism, NF-kappa B - metabolism, Proto-Oncogene Proteins c-rel - metabolism, Receptors, Antigen, B-Cell - immunology, Receptors, Antigen, B-Cell - metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction - immunology, Transcription Factor RelA - metabolism