Details

Autor(en) / Beteiligte

• Chan, Paul K. S.
• Cheung, Jo L. K.
• Cheung, Tak-Hong
• Lo, Keith W. K.
• Yim, So-Fan
• Siu, Shing-Shun N.
• Tang, Julian W.

Titel

Profile of Viral Load, Integration, and E2 Gene Disruption of HPV58 in Normal Cervix and Cervical Neoplasia

Ist Teil von

• The Journal of infectious diseases, 2007-09, Vol.196 (6), p.868-875

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The clinical utility of viral-load and integration status of human papillomavirus (HPV) infection remains uncertain. We examined 75 women infected with HPV58, a worldwide rare type found to be prevalent in cervical cancers in eastern Asia. Viral load was significantly higher for cervical intraepithelial neoplasia (CIN) 1/2, but those for a normal control group and for CIN 3 or cancer overlapped substantially. A pure integrated genome was found for all lesion grades, giving a poor positive predictive value (23.1%) for cancer. The pure episomal form's negative predictive value for cancer was only 76.3%. Mixed patterns of E2 gene disruption were common and often involved the amino-terminal and hinge regions. Disruption of the whole E2 gene was rare and was restricted to high-grade lesions. The HPV58 variant E67-HK-2 was more likely to exist in the pure episomal form. Routinely collected cervical samples contain a heterogeneous population of viruses, hampering the application of viral load and integration testing in clinical settings.