European journal of pharmacology, 2007-09, Vol.570 (1-3), p.38-42
2007
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist
- Ist Teil von
- European journal of pharmacology, 2007-09, Vol.570 (1-3), p.38-42
- Ort / Verlag
- Netherlands
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Piper longum L. has been used as a crude drug for the treatment of the disorder of peripherally poor blood circulation in Asia. In the present study, we examined the effect of piperlongumine, a constituent of P. longum L., on rabbit platelet aggregation. Piperlongumine concentration-dependently inhibited platelet aggregation induced by thromboxane A(2) receptor agonist U46619, but it only slightly inhibited thrombin-induced one. Piperlongumine also inhibited U46619-induced phosphatidylinositol hydrolysis and the binding of [(3)H]SQ29548 to thromboxane A(2) receptor with a similar concentration-dependency to the aggregation. It is assumed that piperlongumine inhibits platelet aggregation as a thromboxane A(2) receptor antagonist.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2999eISSN: 1879-0712DOI: 10.1016/j.ejphar.2007.05.073Titel-ID: cdi_proquest_miscellaneous_68174512
- Format
- –
- Schlagworte
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology, Animals, Bridged Bicyclo Compounds, Heterocyclic, Dioxolanes - pharmacology, Fatty Acids, Unsaturated, Heterocyclic Compounds, 1-Ring - pharmacology, Hydrazines - pharmacology, Male, Phosphatidylinositols - metabolism, Piper - chemistry, Platelet Aggregation - drug effects, Platelet Aggregation Inhibitors - pharmacology, Rabbits, Receptors, Thromboxane A2, Prostaglandin H2 - agonists, Receptors, Thromboxane A2, Prostaglandin H2 - antagonists & inhibitors