Details

Autor(en) / Beteiligte

• Lincoln, Sarah J
• Ross, Owen A
• Milkovic, Nicole M
• Dickson, Dennis W
• Rajput, Alex
• Robinson, Christopher A
• Papapetropoulos, Spiridon
• Mash, Deborah C
• Farrer, Matthew J

Titel

Quantitative PCR-based screening of α -synuclein multiplication in multiple system atrophy

Ist Teil von

• Parkinsonism & related disorders, 2007-08, Vol.13 (6), p.340-342

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Multiple system atrophy (MSA) is by nature a ‘sporadic’ disease with no evidence of familial aggregation observed. However, the α -synuclein locus ( SNCA ) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.