Details

Autor(en) / Beteiligte

• Kim, SJ
• Kim, BS
• Choi, CW
• Choi, J
• Kim, I
• Lee, Y-H
• Kim, JS

Titel

Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type

Ist Teil von

• Annals of oncology, 2007-08, Vol.18 (8), p.1382-1387

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2007

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Background: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low–intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis. Thus, we analyzed Ki-67 expression and proposed a new prognostic model including Ki-67 expression for stage I/II extranodal NK/T-cell lymphoma. Patients and methods: We studied Ki-67 expression and its relationship with prognosis in 50 patients with extranodal NK/T-cell lymphoma. Results: The patients were dichotomized by the median value: low (<65%) versus high Ki-67 (≥65%). High Ki-67 was associated with a worse overall survival (OS; P = 0.021) and disease-free survival (DFS; P = 0.044). In multivariate analysis, Ki-67 expression and primary site of involvement were found to be an independent prognostic factor for OS and DFS (P < 0.05). Based on these results, we proposed a new clinico-pathological prognostic model with Ki-67 expression and the primary site of involvement. It showed a high degree of correlation with worse OS and DFS (P < 0.001). Conclusions: Ki-67 expression is predictive of prognosis, and our prognostic model may become a useful tool for predicting prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type.