Details

Autor(en) / Beteiligte

• Scherer, Christina A
• Magness, Charles L
• Steiger, Kathryn V
• Poitinger, Nicholas D
• Caputo, Christine M
• Miner, Douglas G
• Winokur, Patricia L
• Klinzman, Donna
• McKee, Janice
• Pilar, Christine
• Ward, Patricia A
• Gillham, Martha H
• Haulman, N. Jean
• Stapleton, Jack T
• Iadonato, Shawn P

Titel

Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections

Ist Teil von

• Vaccine, 2007-08, Vol.25 (35), p.6458-6473

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induction of many interferon stimulated genes, as well as enhanced expression of genes involved in proteolysis and antigen presentation. Vaccinia infection was also characterized by a distinct expression signature composed of up-regulation of monocyte response genes, with repression of genes expressed by B and T-cells. In contrast, the yellow fever host response was characterized by a suppression of ribosomal and translation factors, distinguishing this infection from vaccinia and URI. No significant URI-specific signature was observed, perhaps reflecting greater heterogeneity in the study population and etiological agents. Taken together, these data suggest that specific host gene expression signatures may be identified that distinguish one or a small number of virus agents.