Details

Autor(en) / Beteiligte

• Yates, John R.W
• Sepp, Tiina
• Matharu, Baljinder K
• Khan, Jane C
• Thurlby, Deborah A
• Shahid, Humma
• Clayton, David G
• Hayward, Caroline
• Morgan, Joanne
• Wright, Alan F
• Armbrecht, Ana Maria
• Dhillon, Baljean
• Deary, Ian J
• Redmond, Elizabeth
• Bird, Alan C
• Moore, Anthony T

Titel

Complement C3 Variant and the Risk of Age-Related Macular Degeneration

Ist Teil von

• The New England journal of medicine, 2007-08, Vol.357 (6), p.553-561

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A variant on complement factor 3 is associated with age-related macular degeneration, with a population attributable risk of 22%. This finding underlines the importance of complement activation in the pathogenesis of the disease. A variant on complement factor 3 is associated with age-related macular degeneration, with a population attributable risk of 22%. Age-related macular degeneration is the leading cause of visual impairment in the elderly and the most common cause of blindness in Western countries. 1 It affects the macular region of the retina. The macula has a high density of photoreceptors and provides detailed central vision. In the early stages of the disease (referred to as age-related maculopathy), deposits called drusen develop between the retinal pigment epithelium and underlying choroid. 1 Later, the disease is manifested as either extensive atrophy of the retinal pigment epithelium and overlying photoreceptor cells (geographic atrophy) or aberrant choroidal angiogenesis (choroidal neovascularization). 1 Both of these conditions can lead . . .