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Complement C3 Variant and the Risk of Age-Related Macular Degeneration
Ist Teil von
The New England journal of medicine, 2007-08, Vol.357 (6), p.553-561
Ort / Verlag
Boston, MA: Massachusetts Medical Society
Erscheinungsjahr
2007
Quelle
MEDLINE
Beschreibungen/Notizen
A variant on complement factor 3 is associated with age-related macular degeneration, with a population attributable risk of 22%. This finding underlines the importance of complement activation in the pathogenesis of the disease.
A variant on complement factor 3 is associated with age-related macular degeneration, with a population attributable risk of 22%.
Age-related macular degeneration is the leading cause of visual impairment in the elderly and the most common cause of blindness in Western countries.
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It affects the macular region of the retina. The macula has a high density of photoreceptors and provides detailed central vision. In the early stages of the disease (referred to as age-related maculopathy), deposits called drusen develop between the retinal pigment epithelium and underlying choroid.
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Later, the disease is manifested as either extensive atrophy of the retinal pigment epithelium and overlying photoreceptor cells (geographic atrophy) or aberrant choroidal angiogenesis (choroidal neovascularization).
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Both of these conditions can lead . . .