Details

Autor(en) / Beteiligte

• Löffler, Dennis
• Brocke-Heidrich, Katja
• Pfeifer, Gabriele
• Stocsits, Claudia
• Hackermüller, Jörg
• Kretzschmar, Antje K.
• Burger, Renate
• Gramatzki, Martin
• Blumert, Conny
• Bauer, Kay
• Cvijic, Helena
• Ullmann, A. Kerstin
• Stadler, Peter F.
• Horn, Friedemann

Titel

Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

Ist Teil von

• Blood, 2007-08, Vol.110 (4), p.1330-1333

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6–dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3 dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3.