Details

Autor(en) / Beteiligte

• Fowler, Vance G.
• Nelson, Charlotte L.
• McIntyre, Lauren M.
• Kreiswirth, Barry N.
• Monk, Alastair
• Archer, Gordon L.
• Federspiel, Jerome
• Naidich, Steven
• Remortel, Brian
• Rude, Thomas
• Brown, Pamela
• Reller, L. Barth
• Corey, G. Ralph
• Gill, Steven R.

Titel

Potential Associations between Hematogenous Complications and Bacterial Genotype in Staphylococcus aureus Infection

Ist Teil von

• The Journal of infectious diseases, 2007-09, Vol.196 (5), p.738-747

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2007

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background. The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear. Methods. Three hundred seventy-nine S. aureus isolates (125 methicillin-resistant S. aureus [MRSA] and 254 methicillin-susceptible S. aureus [MSSA]) were genotyped by spa typing and multilocus sequence typing. For MRSA isolates, the staphylococcal chromosomal cassette mec (SCCmec) element was also typed. Three clinical categories were identified: nasal carriage only (n = 118), uncomplicated infection (n = 104), and bacteremia with hematogenous complications (n = 157). Results. By use of eBURST, 18 clonal complexes (CCs) were found in 371 isolates. Eight CCs accounted for 89%of isolates and occurred in all clinical categories. CC5 (P = .0025) and CC30 (P = .0308) exhibited a significant trend toward more frequent hematogenous complications. Isolates within spa types 2 and 16 showed the same significant trend and grouped within CC5 and CC30, respectively. SCCmec II isolates also showed the same significant trend compared with SCCmec IV; 96% were CC5 or CC30. Conclusions. Although most S. aureus genotypes exhibited the capacity to cause invasive disease, strains within CC5 and CC30 exhibited a significant trend toward increasing levels of hematogenous complications. Isolates within these CCs were also implicated by use of spa and SCCmec typing. The genetic determinants underlying these findings remain to be demonstrated.