Details

Autor(en) / Beteiligte

• SWANSON, JAMES M., Ph.D
• ELLIOTT, GLEN R., Ph.D., M.D
• GREENHILL, LAURENCE L., M.D
• WIGAL, TIMOTHY, Ph.D
• ARNOLD, L. EUGENE, M.D
• VITIELLO, BENEDETTO, M.D
• HECHTMAN, LILY, M.D
• EPSTEIN, JEFFERY N., Ph.D
• PELHAM, WILLIAM E., Ph.D
• ABIKOFF, HOWARD B., Ph.D
• NEWCORN, JEFFREY H., M.D
• MOLINA, BROOKE S.G., Ph.D
• HINSHAW, STEPHEN P., Ph.D
• WELLS, KAREN C., Ph.D
• HOZA, BETSY, Ph.D
• JENSEN, PETER S., M.D
• GIBBONS, ROBERT D., Ph.D
• HUR, KWAN, Ph.D
• STEHLI, ANNAMARIE, M.P.H
• DAVIES, MARK, M.S
• MARCH, JOHN S., M.D., M.P.H
• CONNERS, C. KEITH, Ph.D
• CARON, MARK, Ph.D
• VOLKOW, NORA D., M.D

Titel

Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up

Ist Teil von

• Journal of the American Academy of Child and Adolescent Psychiatry, 2007-08, Vol.46 (8), p.1015-1027

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2007

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• ABSTRACT Objective: To evaluate the hypothesis of stimulant medication effect on physical growth in the follow-up phase of the Multimodal Treatment Study of Children With ADHD. Method: Naturalistic subgroups were established based on patterns of treatment with stimulant medication at baseline, 14-, 24-, and 36-month assessments: not medicated ( n = 65), newly medicated ( n = 88), consistently medicated ( n = 70), and inconsistently medicated ( n = 147). Analysis of variance was used to evaluate effects of subgroup and assessment time on measures of relative size ( z scores) obtained from growth norms. Results: The subgroup × assessment time interaction was significant for z height ( p <.005) and z weight ( p <.0001), due primarily to divergence of the newly medicated and the not medicated subgroups. These initially stimulant-naïve subgroups had z scores significantly >0 at baseline. The newly medicated subgroup showed decreases in relative size that reached asymptotes by the 36-month assessment, when this group showed average growth of 2.0 cm and 2.7 kg less than the not medicated subgroup, which showed slight increases in relative size. Conclusions: Stimulant-naïve school-age children with Combined type attention-deficit/hyperactivity disorder were, as a group, larger than expected from norms before treatment but show stimulant-related decreases in growth rates after initiation of treatment, which appeared to reach asymptotes within 3 years without evidence of growth rebound.