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High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma
Cancer, 2006-07, Vol.107 (1), p.37-45
Parker, Alexander S.
Kosari, Farhad
Lohse, Christine M.
Houston Thompson, R.
Kwon, Eugene D.
Murphy, Linda
Riehle, Darren L.
Blute, Michael L.
Leibovich, Bradley C.
Vasmatzis, George
Cheville, John C.
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Parker, Alexander S.
Kosari, Farhad
Lohse, Christine M.
Houston Thompson, R.
Kwon, Eugene D.
Murphy, Linda
Riehle, Darren L.
Blute, Michael L.
Leibovich, Bradley C.
Vasmatzis, George
Cheville, John C.
Titel
High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma
Ist Teil von
Cancer, 2006-07, Vol.107 (1), p.37-45
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
BACKGROUND In a previous study of gene array data, the authors identified survivin as a candidate marker of aggressiveness in clear cell renal cell carcinoma (ccRCC). What remained in question was whether survivin expression at the protein level is an independent predictor of disease progression and cancer‐specific survival. METHODS Between 1990 and 1994, 312 patients underwent nephrectomy for ccRCC at Mayo Clinic Rochester and had paraffin tissue available. The authors performed immunohistochemistry with antisurvivin antibody, quantitated the expression by using an image‐analysis system, and analyzed the association of survivin expression with disease progression and cancer‐specific survival. RESULTS Within the cohort, 97 patients (31.1%) had high levels of survivin expression. Patients who had high survivin expression levels were at significantly increased risk of death from RCC compared with patients who had low expression levels (risk ratio [RR], 5.3; 95% confidence interval [95% CI], 3.5–7.9). The 5‐year cancer‐specific survival rate was 43.0% for patients with high survivin expression and 87.2% for patients with low survivin expression. In multivariate analysis, survivin expression remained associated with death from RCC even after adjusting for the Eastern Cooperative Oncology Group performance status; 2002 Tumor, Lymph Node, Metastases (TNM) stage groupings and nuclear grade (RR, 2.4; 95%CI, 1.5–3.8); and the Mayo Clinic composite TNM stage groupings, tumor size, nuclear grade, and tumor necrosis (SSIGN) score (RR, 1.8; 95%CI, 1.1–2.9). Among 273 patients who had localized ccRCC, survivin expression was associated significantly with cancer progression (RR, 3.9; 95%CI, 2.4–6.2). CONCLUSIONS Survivin expression is an independent predictor of ccRCC progression and death from RCC. Thus, survivin has the potential to offer additional prognostic information and to provide a novel target for the development of new adjuvant therapies. Cancer 2006. © 2006 American Cancer Society. The results of this study indicated that survivin expression was an independent predictor of disease progression in patients with clear cell renal cell carcinoma (RCC) and of death from RCC. Survivin has the potential to offer additional prognostic information and may provide a novel target for the development of new adjuvant therapies.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.21952
Titel-ID: cdi_proquest_miscellaneous_68101937
Format
–
Schlagworte
Aged
,
Carcinoma, Renal Cell - mortality
,
Carcinoma, Renal Cell - pathology
,
Carcinoma, Renal Cell - surgery
,
clear cell renal cell carcinoma
,
Cohort Studies
,
Disease Progression
,
Female
,
Humans
,
Immunohistochemistry
,
Inhibitor of Apoptosis Proteins
,
Kidney Neoplasms - mortality
,
Kidney Neoplasms - pathology
,
Kidney Neoplasms - surgery
,
Male
,
Microtubule-Associated Proteins - analysis
,
Microtubule-Associated Proteins - biosynthesis
,
Middle Aged
,
Neoplasm Proteins - analysis
,
Neoplasm Proteins - biosynthesis
,
Nephrectomy
,
nuclear grade
,
Predictive Value of Tests
,
prognostic biomarkers
,
protein isoforms
,
Survival Rate
,
survivin expression
,
Treatment Outcome
,
Up-Regulation
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