Details

Autor(en) / Beteiligte

• Boot, Hein J
• Wallenburg, Iris
• de Melker, Hester E
• Mangen, Marie-José M
• Gerritsen, Annette A.M
• van der Maas, Nicoline A
• Berkhof, Johannes
• Meijer, Chris J.L.M
• Kimman, Tjeerd G

Titel

Assessing the introduction of universal human papillomavirus vaccination for preadolescent girls in The Netherlands

Ist Teil von

• Vaccine, 2007-08, Vol.25 (33), p.6245-6256

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Abstract A persistent infection with human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. Clinical trials with HPV-vaccines have been very successful in preventing persistent HPV16/18 infections, the two most oncogenic HPV-genotypes. We assessed the introduction of universal HPV-vaccination for preadolescent girls in the Dutch National Immunization Programme. Long-term vaccine efficacy, the need and extent of a catch-up programme for young women, and the impact of vaccination on the cervical cancer screening programme are major unresolved issues. Preliminary conservative estimates (80% vaccine efficacy and no effects on the screening programme, transmission rate, non-cervical cancer incidence, and cross protection) predict an acceptable cost-effectiveness ratio for universal vaccination of preadolescent girls.