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Histopathology of BRCA1- and BRCA2-associated breast cancer
Ist Teil von
Critical reviews in oncology/hematology, 2006-07, Vol.59 (1), p.27-39
Ort / Verlag
Shannon: Elsevier Ireland Ltd
Erscheinungsjahr
2006
Quelle
MEDLINE
Beschreibungen/Notizen
Hereditary breast carcinomas that are attributable to
BRCA1/
2 mutations have their own morphological and immunohistochemical characteristics.
BRCA1-associated carcinomas are poorly differentiated infiltrating ductal carcinomas that frequently show morphological features of typical or atypical medullary carcinoma.
BRCA2-associated breast carcinomas tend to be of higher grade than sporadic age-matched controls.
BRCA1
tumors have been found to be more frequently estrogen receptor- and progesterone receptor-negative, and p53-positive than are age-matched controls, whereas these differences are not usually found in
BRCA2-associated tumors. In addition,
BRCA1- and
BRCA2-associated breast carcinomas show a low frequency of HER2 expression. Most
BRCA1 breast carcinomas are characterized by the expression of basal (myoepithelial) markers, such as cytokeratin 5/6 and or P-cadherin. These features could be used to distinguish patients who are likely to carry a
BRCA1 or
BRCA2 germline mutation, thus indicating which gene should be screened for first in families with a high incidence of breast and ovarian cancer.