Details

Autor(en) / Beteiligte

• MÜLLER-BERGHAUS, Jan
• EHLERT, Katrin
• UGUREL, Selma
• UMANSKY, Viktor
• BUCUR, Mariana
• SCHIRRMACHER, Volker
• BECKHOVE, Philipp
• SCHADENDORF, Dirk

Titel

Melanoma-reactive T cells in the bone marrow of melanoma patients : Association with disease stage and disease duration

Ist Teil von

• Cancer research (Chicago, Ill.), 2006-06, Vol.66 (12), p.5997-6001

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2006

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Using IFN-gamma enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients.