Details

Autor(en) / Beteiligte

• Paek, Sun Ha
• Chung, Hyun‐Tai
• Jeong, Sang Soon
• Park, Chul‐Kee
• Kim, Chae‐Yong
• Kim, Jeong Eun
• Kim, Dong Gyu
• Jung, Hee‐Won

Titel

Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma

Ist Teil von

• Cancer, 2005-08, Vol.104 (3), p.580-590

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2005

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• BACKGROUND To evaluate the hearing preservation rate and to determine its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in patients with vestibular schwannoma, the authors used a prospective study design to analyze these patients. METHODS Between December 1997 and January 2002, 25 patients with vestibular schwannoma with serviceable hearing were enrolled in the current study. The median tumor volume was 3.0 cc (0.16–9.1 cc). The prescription dose was 12.0 ± 0.7 gray at an isodose line of 49.8 ± 1.1%. The tumor control rate and complications were evaluated by focusing on hearing preservation and its prognostic factors. RESULTS Based on radiologic study, the tumor control rate was 92% during the median follow‐up period of 45 months. The trigeminal and facial nerve preservation rates were 95% and 100%, respectively. Thirteen (52%) of the 25 patients preserved serviceable hearing and 9 (36%) patients retained their pre‐GK G‐R grade levels after GK SRS. However, 16 patients showed hearing deterioration > 20 dB within 3–6 months and this trend continued for 24 months after the treatment. The maximum radiotherapy dose delivered to the cochlear nucleus was the single, significant prognostic factor of hearing deterioration. CONCLUSIONS The authors concluded that a more sophisticated strategy to prevent hearing deterioration during the first 6 months post‐GK SRS is necessary to improve long‐term hearing preservation. Cancer 2005. © 2005 American Cancer Society. Using a prospective study design, the authors evaluated the hearing preservation rate and determined its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in a series of patients with vestibular schwannoma. The results indicated that a more sophisticated strategy to prevent hearing deterioration during the first 6 months post‐GK SRS is necessary to improve long‐term hearing preservation.