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Successful carboplatin desensitization in patients with proven carboplatin allergy
Cancer, 2005-08, Vol.104 (3), p.640-643
Confino‐Cohen, Ronit
Fishman, Amiram
Altaras, Marco
Goldberg, Arnon
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Confino‐Cohen, Ronit
Fishman, Amiram
Altaras, Marco
Goldberg, Arnon
Titel
Successful carboplatin desensitization in patients with proven carboplatin allergy
Ist Teil von
Cancer, 2005-08, Vol.104 (3), p.640-643
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND Carboplatin is one of the most useful and well tolerated cytotoxic drugs for gynecologic malignancies. Hypersensitivity to carboplatin is not rare among patients receiving multiple recurrent treatments with this drug. The aim of the current study was to offer a safe and convenient carboplatin desensitization strategy to patients with a proven allergic reaction to this drug. METHODS Patients with an immediate objective allergic reaction to carboplatin were skin tested with the drug. A 6‐hour carboplatin desensitization protocol was administered to the patients with a carboplatin‐positive skin test on each of the following treatment courses. RESULTS Twenty‐three patients with an allergic reaction to carboplatin and a positive skin test were included in the current study. Twenty patients (86.9%) were desensitized. One patient developed a mild urticarial rash. Nineteen patients tolerated 80 desensitization courses uneventfully. CONCLUSIONS The data presented a successful desensitization protocol for individuals with a proven allergic reaction to carboplatin. The protocol was safe and convenient and offered an effective therapeutic strategy to patients who required this drug. Cancer 2005. © 2005 American Cancer Society. The data presented a successful desensitization protocol for individuals with a proven allergic reaction to carboplatin. The protocol was safe and convenient, and offered an effective therapeutic strategy to patients who required this drug.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.21168
Titel-ID: cdi_proquest_miscellaneous_68071430
Format
–
Schlagworte
Adult
,
Aged
,
allergy
,
Biological and medical sciences
,
carboplatin
,
Carboplatin - immunology
,
Carboplatin - therapeutic use
,
carboplatin desensitization
,
Desensitization, Immunologic
,
Drug Hypersensitivity - immunology
,
Drug Hypersensitivity - prevention & control
,
Endometrial Neoplasms - drug therapy
,
Endometrial Neoplasms - immunology
,
Female
,
Humans
,
hypersensitivity
,
Medical sciences
,
Middle Aged
,
Ovarian Neoplasms - drug therapy
,
Ovarian Neoplasms - immunology
,
Peritoneal Neoplasms - drug therapy
,
Peritoneal Neoplasms - immunology
,
Skin Tests
,
Tumors
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