Details

Autor(en) / Beteiligte

• Bang, Duhee
• Pentelute, Brad L.
• Kent, Stephen B. H.

Titel

Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins

Ist Teil von

• Angewandte Chemie (International ed.), 2006-06, Vol.45 (24), p.3985-3988

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Converging on the goal: New chemistry enables the key Cys‐peptide‐(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.