Biological chemistry, 2006-05, Vol.387 (5), p.485-497
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Protein aggregation in crowded environments
- Ist Teil von
- Biological chemistry, 2006-05, Vol.387 (5), p.485-497
- Ort / Verlag
- Germany: Walter de Gruyter
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1431-6730eISSN: 1437-4315DOI: 10.1515/BC.2006.064Titel-ID: cdi_proquest_miscellaneous_68037934
- Format
- –
- Schlagworte
- Algorithms, Animals, excluded volume, Humans, macromolecular crowding, Macromolecular Substances - chemistry, Macromolecular Substances - metabolism, Models, Biological, Models, Molecular, molecular chaperones, Molecular Chaperones - chemistry, Molecular Chaperones - metabolism, protein aggregation, Protein Binding, Protein Denaturation, Protein Folding, Proteins - chemistry, Proteins - metabolism