FEBS letters, 2006-06, Vol.580 (14), p.3361-3367
2006
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- Autor(en) / Beteiligte
- Titel
- CYP4A11 is repressed by retinoic acid in human liver cells
- Ist Teil von
- FEBS letters, 2006-06, Vol.580 (14), p.3361-3367
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- CYP4A11, the major fatty acid ω-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are both poorly understood. We studied the effects of retinoids on the regulation of CYP4A11 in the human hepatoma cell line HepaRG. Treatment of HepaRG cells with all- trans-retinoic acid resulted in a strong decrease in CYP4A11 gene expression and apoprotein content and, furthermore, was associated with a 50% decrease in the microsomal lauric acid hydroxylation activity. Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2006.05.006Titel-ID: cdi_proquest_miscellaneous_68037846
- Format
- –
- Schlagworte
- 15-deoxyprostaglandine J2, 2-bromopalmitate, 2BrP, 9-cis-RA, 9-cis-retinoic acid, all-trans-retinoic acid, ATRA, Bezaf, bezafibrate, Carcinoma, Hepatocellular - enzymology, Carcinoma, Hepatocellular - pathology, Cell Line, Tumor, Chromatography, High Pressure Liquid, CYP, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System - genetics, Cytochrome P450, Dose-Response Relationship, Drug, FAS, Fatty acid hydroxylase, fatty acid synthase, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, HepaRG, Human hepatoma cells, Humans, lauric acid ω-hydroxylase, leukotriene B4, Liver, Liver - drug effects, Liver - enzymology, Liver Neoplasms - enzymology, Liver Neoplasms - pathology, LTB4, peroxisome proliferator-activated receptor, PGJ2, PPAR, PPAR alpha - metabolism, RAR, RARE, Retinoic acid, retinoic acid receptor, retinoic acid response element, retinoid X receptor, RNA, Messenger - genetics, RXR, Tretinoin - pharmacology, ω-LAH