Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3668-3673
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3668-3673
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2006.04.061Titel-ID: cdi_proquest_miscellaneous_68035094
- Format
- –
- Schlagworte
- Antagonist, Biological and medical sciences, Hormones. Endocrine system, Humans, Medical sciences, Melanin-concentrating hormone receptor 1, Pharmacology. Drug treatments, Piperidines - chemical synthesis, Piperidines - pharmacology, Receptors, Pituitary Hormone - antagonists & inhibitors, Structure-Activity Relationship