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Smoking affects treatment outcome in patients with advanced nonsmall cell lung cancer
Cancer, 2006-06, Vol.106 (11), p.2428-2436
Tsao, Anne S.
Liu, Diane
Lee, J. Jack
Spitz, Margaret
Hong, Waun Ki
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Tsao, Anne S.
Liu, Diane
Lee, J. Jack
Spitz, Margaret
Hong, Waun Ki
Titel
Smoking affects treatment outcome in patients with advanced nonsmall cell lung cancer
Ist Teil von
Cancer, 2006-06, Vol.106 (11), p.2428-2436
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND The purpose of the current study was to determine whether smoking during chemotherapy or chemoradiation therapy for nonsmall cell lung cancer (NSCLC) affects treatment outcome. METHODS The authors reviewed the medical records of patients with NSCLC (AJCC Stage III or IV) who were treated with frontline chemotherapy or chemoradiation therapy at the University of Texas M. D. Anderson Cancer Center between January 1993 and December 2002. Treatment type, response, progression‐free survival, and overall survival (OS) were correlated with patient demographic characteristics, clinical features, and smoking habits at the time of diagnosis and during therapy. RESULTS Of 1370 patients who were eligible for analysis, 497 received chemoradiation therapy and 873 received chemotherapy. In the chemoradiation group, 6% of patients were never‐smokers, 45% were former smokers, and 49% were current smokers. Multivariate analysis demonstrated no prognostic effect of smoking status on treatment response or OS rates in the chemoradiation therapy group. In the chemotherapy group, 16% of patients were never‐smokers, 42% were former smokers, and 42% were current smokers; 20% of patients continued to smoke during therapy. Never‐smokers had higher response rates (19% vs. 8% vs. 12%; P = .004) and lower rates of progressive disease (49% vs. 65% vs. 66%; P = .002) than former and current smokers, respectively. The OS rates were found to be higher among never‐smokers (P <.0001), women (P = .002), and those with a better Eastern Cooperative Oncology Group (ECOG) performance status (P <.0001). The multivariate Cox model indicated that with adjustment for age, gender, stage of disease, and ECOG performance status, the hazard ratio was 1.47 for former smokers (P = .003) and 1.55 for current smokers (P = .0004). Active smoking during therapy did not appear to impact outcome. CONCLUSIONS Never‐smokers were found to have an improved outcome over smokers when treated with chemotherapy. Cancer 2006. © 2006 American Cancer Society. Never‐smoking history in patients with nonsmall cell lung cancer was found to confer an improved clinical outcome when the patients were treated with chemotherapy. Active smoking during chemotherapy or chemoradiation therapy did not appear to affect clinical outcome.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.21884
Titel-ID: cdi_proquest_miscellaneous_68020545
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
Aged, 80 and over
,
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
,
Biological and medical sciences
,
Carcinoma, Non-Small-Cell Lung - drug therapy
,
Carcinoma, Non-Small-Cell Lung - radiotherapy
,
Carcinoma, Non-Small-Cell Lung - therapy
,
chemoradiation therapy
,
chemotherapy
,
Cohort Studies
,
Female
,
Humans
,
Lung Neoplasms - drug therapy
,
Lung Neoplasms - radiotherapy
,
Lung Neoplasms - therapy
,
Male
,
Medical sciences
,
Middle Aged
,
nonsmall cell lung cancer
,
smoking
,
Smoking - adverse effects
,
Survival Rate
,
Tobacco, tobacco smoking
,
Toxicology
,
Treatment Outcome
,
Tumors
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