Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
The zebrafish gene claudinj is essential for normal ear function and important for the formation of the otoliths
Ist Teil von
Mechanisms of development, 2005-07, Vol.122 (7), p.949-958
Ort / Verlag
Ireland: Elsevier Ireland Ltd
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
We have identified a mutation in the zebrafish gene
claudinj generated by retroviral integration. Mutant embryos display otoliths severely reduced in size, no response to tapping stimulus, and an inability to balance properly suggesting vestibular and hearing dysfunction. Antisense in situ hybridization to the
cldnj gene showed expression first in the otic placode and later asymmetric expression in the otic vesicle. Morpholino inhibition of
claudinj expression showed similar defects in otolith formation. Phylogenetic analysis of claudin sequences from multiple species demonstrates that
claudinj was part of a gene expansion that began in the common ancestor of fish and humans, but additional fish specific gene duplications must have also occurred.