Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3588-3591
2005
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- Autor(en) / Beteiligte
- Titel
- Neuroprotective effects of naturally occurring biflavonoids
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3588-3591
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We examined the neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid β peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid β, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer’s disease. We examined neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid β peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid β, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer’s disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2005.05.078Titel-ID: cdi_proquest_miscellaneous_68012093
- Format
- –
- Schlagworte
- Alzheimer Disease - drug therapy, Alzheimer’s disease, Amentoflavone, Amyloid beta-Peptides - metabolism, Amyloid beta-Peptides - pharmacology, Biflavonoids, Biflavonoids - chemistry, Biflavonoids - pharmacology, Biological and medical sciences, Brain Ischemia - drug therapy, Cell Death - drug effects, Dose-Response Relationship, Drug, Flavonoids, Humans, Ischemic stroke, Medical sciences, Neurodegenerative Diseases - drug therapy, Neurons - cytology, Neurons - drug effects, Neuropharmacology, Neuroprotection, Neuroprotective agent, Neuroprotective Agents - chemistry, Neuroprotective Agents - pharmacology, Oxidative Stress - drug effects, Pharmacology. Drug treatments, Tumor Cells, Cultured