Details

Autor(en) / Beteiligte

• Karjalainen, Jussi
• Virta, Miia
• Pessi, Tanja
• Hulkkonen, Janne
• Nieminen, Markku M.
• Hurme, Mikko

Titel

Childhood cat exposure–related tolerance is associated with IL1A and IL10 polymorphisms

Ist Teil von

• Journal of allergy and clinical immunology, 2005-07, Vol.116 (1), p.223-225

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• [...]it has been shown that the presence of a cat in the home might decrease the risk of sensitization to cat allergen,1 and exposure to domestic pets in the first year of life significantly reduces the risk of allergic sensitization in children.2,3 IL-1 is a potent inducer of IL-10 and also plays a role in early T-cell priming, which has been considered to be one key point of interest in the development of tolerance.4 We have previously studied IL1A (G/T base exchange at +4845) and IL10 promoter region polymorphism in atopy and asthma.5,6 Now we investigated whether the genes encoding the cytokines IL-1α (IL1A) and IL-10 (IL10) affect exposure-related tolerance. [...]we analyzed the association of cat and dog exposure in childhood with the sensitization to cat and dog allergens in a population-based sample of adult asthmatic subjects (n=245) and their nonasthmatic control subjects (n=405).