Science (American Association for the Advancement of Science), 2006-05, Vol.312 (5776), p.1051-1054
2006
Details
- Autor(en) / Beteiligte
- Titel
- Bruchpilot Promotes Active Zone Assembly, Ca²⁺ Channel Clustering, and Vesicle Release
- Ist Teil von
- Science (American Association for the Advancement of Science), 2006-05, Vol.312 (5776), p.1051-1054
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2006
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The molecular organization of presynaptic active zones during calcium influx-triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction resolution STED (stimulated emission depletion) fluorescence microscopy. At brp mutant active zones, electron-dense projections (T-bars) were entirely lost, Ca²⁺ channels were reduced in density, evoked vesicle release was depressed, and short-term plasticity was altered. BRP-like proteins seem to establish proximity between Ca²⁺ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1126308Titel-ID: cdi_proquest_miscellaneous_67992964
- Format
- –
- Schlagworte
- Action Potentials, Animals, Biological and medical sciences, Brunchpilot protein, Calcium, calcium channels, Calcium Channels - metabolism, Cell membranes. Ionic channels. Membrane pores, Cell structures and functions, cytochemistry, Drosophila, Drosophila melanogaster, Drosophila Proteins - genetics, Drosophila Proteins - physiology, Electric current, Female, Fundamental and applied biological sciences. Psychology, Glutamate receptors, insect proteins, Insects, Larva, Male, Microscopy, Models, Neurological, Molecular and cellular biology, Mutation, Nerve Tissue Proteins - metabolism, Nerve Tissue Proteins - physiology, Neurons, neurophysiology, Neuroscience, Neurosciences, neurotransmitter release, Neurotransmitters, Presynaptic Terminals - metabolism, Proteins, Receptors, synapse, Synapses, Synapses - metabolism, Synapses - physiology, Synapses - ultrastructure, synaptic transmission, Synaptic Vesicles - metabolism