Details

Autor(en) / Beteiligte

• Frisancho-Kiss, Sylvia
• Nyland, Jennifer F
• Davis, Sarah E
• Barrett, Masheka A
• Gatewood, Shannon J. L
• Njoku, Dolores B
• Cihakova, Daniela
• Silbergeld, Ellen K
• Rose, Noel R
• Fairweather, DeLisa

Titel

Cutting Edge: T Cell Ig Mucin-3 Reduces Inflammatory Heart Disease by Increasing CTLA-4 during Innate Immunity

Ist Teil von

• The Journal of immunology (1950), 2006-06, Vol.176 (11), p.6411-6415

Ort / Verlag

United States: Am Assoc Immnol

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Autoimmune diseases can be reduced or even prevented if proinflammatory immune responses are appropriately down-regulated. Receptors (such as CTLA-4), cytokines (such as TGF-beta), and specialized cells (such as CD4+CD25+ T regulatory cells) work together to keep immune responses in check. T cell Ig mucin (Tim) family proteins are key regulators of inflammation, providing an inhibitory signal that dampens proinflammatory responses and thereby reducing autoimmune and allergic responses. We show in this study that reducing Tim-3 signaling during the innate immune response to viral infection in BALB/c mice reduces CD80 costimulatory molecule expression on mast cells and macrophages and reduces innate CTLA-4 levels in CD4+ T cells, resulting in decreased T regulatory cell populations and increased inflammatory heart disease. These results indicate that regulation of inflammation in the heart begins during innate immunity and that Tim-3 signaling on cells of the innate immune system critically influences regulation of the adaptive immune response.