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Immunoglobulin class-switch recombination occurs in mantle cell lymphomas
The Journal of pathology, 2006-06, Vol.209 (2), p.250-257
Klapper, W
Szczepanowski, M
Heidorn, K
Müschen, M
Liedtke, S
Sotnikova, A
Andersen, NS
Greeve, J
Parwaresch, R
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Klapper, W
Szczepanowski, M
Heidorn, K
Müschen, M
Liedtke, S
Sotnikova, A
Andersen, NS
Greeve, J
Parwaresch, R
Titel
Immunoglobulin class-switch recombination occurs in mantle cell lymphomas
Ist Teil von
The Journal of pathology, 2006-06, Vol.209 (2), p.250-257
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2006
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Mantle cell lymphoma (MCL) is an IgM‐expressing B cell lymphoma that originates from naive B cells and responds poorly to chemotherapy. We show here that several MCLs harbour isotype‐switched subclones. Similar to the situation in normal B cells, in vitro stimulation of MCL cell lines with CD40 ligand (CD40L) and interleukin‐4 induced expression of activation‐induced cytidine deaminase (AID) and germline transcription at the immunoglobulin heavy chain gene locus. Additionally, the occurrence of switch‐circle transcripts and mature IgG transcripts after stimulation indicated ongoing class‐switch recombination in mantle cell lymphoma cell lines. Furthermore, stimulation of primary MCL cells in vitro induced expression of class‐switched IgG mRNA in the tumour cells. Our data indicate that mantle cell lymphomas have retained the ability to undergo class‐switch recombination if appropriate stimuli, such as the CD40 ligand, are provided. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.1961
Titel-ID: cdi_proquest_miscellaneous_67980673
Format
–
Schlagworte
activation-induced cytidine deaminase
,
Biological and medical sciences
,
CD40 Antigens - immunology
,
Cell Line, Tumor
,
class-switch
,
Cytidine Deaminase - immunology
,
Dendritic Cells, Follicular - immunology
,
Genes, Immunoglobulin Heavy Chain - genetics
,
Genes, Immunoglobulin Heavy Chain - immunology
,
Hematologic and hematopoietic diseases
,
Humans
,
immunoglobulin
,
Immunoglobulin Class Switching - genetics
,
Immunoglobulin Class Switching - immunology
,
Immunoglobulin G - genetics
,
Immunoglobulin G - immunology
,
Immunohistochemistry - methods
,
Interleukin-4 - immunology
,
Investigative techniques, diagnostic techniques (general aspects)
,
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
,
Lymphoma, Mantle-Cell - genetics
,
Lymphoma, Mantle-Cell - immunology
,
mantle cell lymphoma
,
Medical sciences
,
Mutation - genetics
,
Mutation - immunology
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
Recombination, Genetic - genetics
,
Recombination, Genetic - immunology
,
Reverse Transcriptase Polymerase Chain Reaction - methods
,
RNA, Messenger - analysis
,
RNA, Neoplasm - analysis
,
Transcription, Genetic - genetics
,
Transcription, Genetic - immunology
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