Details

Autor(en) / Beteiligte

• Kim, V. Narry

Titel

MicroRNA biogenesis: coordinated cropping and dicing

Ist Teil von

• Nature reviews. Molecular cell biology, 2005-05, Vol.6 (5), p.376-385

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.