Details

Autor(en) / Beteiligte

• Osmanliev, D.P.
• Joyce, H.
• Watson, R.A.
• Pride, N.B.

Titel

Evolution of changes in carbon monoxide transfer factor in men with chronic obstructive pulmonary disease

Ist Teil von

• Respiratory medicine, 2005-08, Vol.99 (8), p.1053-1060

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2005

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Progression of chronic obstructive pulmonary disease (COPD) has been studied predominantly by following change in forced expiratory volume in 1 s (FEV 1) which reflects both primary airway disease and associated alveolar disease. Carbon monoxide transfer ( T lco) (the product of the transfer coefficient K co and alveolar volume V a) is the only simple, widely available test of alveolar function, but few studies have followed long-term changes in an individual. Seventeen middle-aged men with moderate chronic airflow obstruction (mean FEV 1 56% of predicted values) were observed with yearly measurements of FEV 1, T lco and K co over a mean of 18.9 yr. At the end of follow-up FEV 1 had fallen to 29% of predicted values. V a, measured by single breath dilution, fell in each man. K co at recruitment ranged from 41% to 110% predicted and remained >75% predicted in eight men at the end of follow-up supporting a phenotype of COPD with predominant airway disease and little emphysema. Fall in FEV 1 was faster (2.03% predicted FEV 1/yr) in seven men with low initial K co<75% pred. than in men with initial K co>75% pred. (1.14% predicted FEV 1/yr, P = 0.006 ). Repeated measurements of CO transfer in an individual should increase the present poor knowledge of the contribution of alveolar disease to the progression of chronic airflow obstruction.