British journal of psychiatry, 2006-05, Vol.188 (5), p.484-485
2006
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry
- Ist Teil von
- British journal of psychiatry, 2006-05, Vol.188 (5), p.484-485
- Ort / Verlag
- England: RCP
- Erscheinungsjahr
- 2006
- Quelle
- Applied Social Sciences Index & Abstracts (ASSIA)
- Beschreibungen/Notizen
- The genesis of Tourette syndrome is still unknown, but a core role for the pathways of cortico-striatal-thalamic-cortical circuitry (CSTC) is supposed. Volume-rendering magnetic resonance imaging data-sets were analysed in 14 boys with Tourette syndrome and 15 age-matched controls using optimised voxel-based morphometry. Locally increased grey-matter volumes (corrected P < 0.001) were found bilaterally in the ventral putamen. Regional decreases in grey matter were observed in the left hippocampal gyrus. This unbiased analysis confirmed an association between striatal abnormalities and Tourette syndrome, and the hippocampal volume alterations indicate an involvement of temporolimbic pathways of the CSTC in the syndrome.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-1250eISSN: 1472-1465DOI: 10.1192/bjp.bp.105.008813Titel-ID: cdi_proquest_miscellaneous_67920415
- Format
- –
- Schlagworte
- Adolescent, Age, Attention deficit hyperactivity disorder, Boys, Brain - pathology, Child, Children & youth, Comorbidity, Cortex, Gilles de la Tourette syndrome, Hippocampus, Hippocampus - pathology, Humans, Imaging, Three-Dimensional - methods, Magnetic resonance imaging, Magnetic Resonance Imaging - methods, Male, Morphology, Morphometry, Neostriatum, NMR, Nuclear magnetic resonance, Patients, Psychiatry, Putamen, Substantia grisea, Thalamus, Tourette syndrome, Tourette Syndrome - pathology, Tourette's syndrome, Visual Cortex - pathology