Details

Autor(en) / Beteiligte

• Liu, D. P.
• Majewski, P.
• O'Neill, B. K.
• Ngothai, Y.
• Colby, C. B.

Titel

The optimal SAM surface functional group for producing a biomimetic HA coating on Ti

Ist Teil von

• Journal of biomedical materials research, 2006-06, Vol.77A (4), p.763-772

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Commercial interest is growing in biomimetic methods that employ self assembled mono‐layers (SAMs) to produce biocompatible HA coatings on Ti‐based orthopedic implants. Recently, separate studies have considered HA formation for various SAM surface functional groups. However, these have often neglected to verify crystallinity of the HA coating, which is essential for optimal bioactivity. Furthermore, differing experimental and analytical methods make performance comparisons difficult. This article investigates and evaluates HA formation for four of the most promising surface functional groups: OH, SO3H, PO4H2 and COOH. All of them successfully formed a HA coating at Ca/P ratios between 1.49 and 1.62. However, only the SO3H and COOH end groups produced a predominantly crystalline HA. Furthermore, the COOH end group yielded the thickest layer and possessed crystalline characteristics very similar to that of the human bone. The COOH end group appears to provide the optimal SAM surface interface for nucleation and growth of biomimetic crystalline HA. Intriguingly, this finding may lend support to explanations elsewhere of why human bone sialoprotein is such a potent nucleator of HA and is attributed to the protein's glutamic acid‐rich sequences. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006