Details

Autor(en) / Beteiligte

• Rumbold, Alice R
• Crowther, Caroline A
• Haslam, Ross R
• Dekker, Gustaaf A
• Robinson, Jeffrey S

Titel

Vitamins C and E and the Risks of Preeclampsia and Perinatal Complications

Ist Teil von

• The New England journal of medicine, 2006-04, Vol.354 (17), p.1796-1806

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this multicenter, randomized trial, supplementation with vitamins C and E during pregnancy did not reduce the risks of preeclampsia in nulliparous women, intrauterine growth restriction, or a composite end point of death or other serious outcomes in the infants. These data, therefore, fail to support the idea that such supplementation is beneficial. Supplementation with vitamins C and E during pregnancy did not reduce the risks of preeclampsia in nulliparous women, intrauterine growth restriction, or a composite end point of death or other serious outcomes in the infants. Preeclampsia is a multisystem disorder characterized by hypertension and proteinuria occurring in the second half of pregnancy. 1 Nulliparity is a recognized risk factor. Preeclampsia carries risks of serious complications and death for the mother. 1 – 3 For the infant, risks include death, preterm birth, intrauterine hypoxia, and poor intrauterine growth. 1 , 4 , 5 The pathogenesis of preeclampsia involves inadequate trophoblast invasion, 6 often leading to poor placental perfusion; generalized endothelial dysfunction 7 ; and immune maladaptation and inflammation. 8 Oxidative stress, characterized by excessive production of reactive oxygen species, coupled with inadequate or overwhelmed antioxidant defense mechanisms, has been proposed as a link between these . . .