Details

Autor(en) / Beteiligte

• Thaler, K.
• Dinnewitzer, A.
• Oberwalder, M.
• Weiss, E. G.
• Nogueras, J. J.
• Wexner, S. D.

Titel

Assessment of long-term quality of life after laparoscopic and open surgery for Crohn's disease

Ist Teil von

• Colorectal disease, 2005-07, Vol.7 (4), p.375-381

Ort / Verlag

Oxford, UK: Blackwell Science Ltd

Erscheinungsjahr

2005

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Objective  Surgery for Crohn's disease (CD) is associated with a high recurrence rate and quality of life (QOL) in these patients is controversial. The aim of this study was to assess QOL in patients after laparoscopic and open surgery for CD by two different validated instruments, a generic nonspecific score and a specific gastrointestinal QOL index. Patients and methods  Patients with CD who underwent elective laparoscopic or open ileocaecal resection with primary anastomosis between 1992 and 2000 were followed for recurrence and surgery‐related complications. QOL was assessed by the SF‐36 Health Survey containing a mental (MCS) and a physical (PCS) component summary score and by the Gastrointestinal Quality of Life Index (GIQLI) developed by Eypasch. Results  Thirty‐seven patients with a mean age of 48.8 ± 18.4 years including 23 females and 14 males were evaluated at a mean follow‐up of 42.6 ±25.8 months (minimum of 8 months). Twenty‐one (57%) patients underwent laparoscopic resection and 16 (43%) open surgery. Both groups were well matched for age, gender, ASA class and body mass index. Fourteen (38%) patients developed recurrent disease and 3 (8%) had postoperative incisional hernias. Overall, QOL scores were 103 ± 26.8 for the GIQLI, 47.2 ± 11.8 for the PCS, and 49.2 ± 11.5 for the MCS. The GIQLI correlated well with the SF36, correlation coefficient = 0.68 for GIQLI vs PCS (95% CI, 0.41,0.95) and 0.67 for GIQLI vs MCS (95%CI, 0.39, 0.95), respectively. When compared to the general US population, mean GIQLI scores (−13.8, P = 0.002) and mean PCS scores (−4.7, P = 0.001) were significantly lower in these patients than in healthy individuals. In a multivariate analysis of impact factors on QOL, recurrence within the follow‐up period was the single significant determinant reducing the PCS (−35.1, P = 0.026) and the GIQLI (−36.1, P =0.018). Conclusion  QOL is significantly reduced in patients with CD at long‐term follow‐up after both laparoscopic and open surgery. Recurrence is the only factor adversely affecting QOL of CD patients in remission irrespective of the operative technique applied.