Details

Autor(en) / Beteiligte

• Montel, Florian
• Beaudegnies, Renaud
• Kessabi, Jilali
• Martin, Benjamin
• Muller, Eric
• Wendeborn, Sebastian
• Jung, Pierre M. J

Titel

New Method Based on 1-(Trimethysilyl)alk-1-yne To Prepare 1,4-Skipped Diynes

Ist Teil von

• Organic letters, 2006-04, Vol.8 (9), p.1905-1908

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We have developed a novel reaction between a terminal TMS-alkyne and a propargyl halide in the presence of a fluoride source and a catalytic amount of copper iodide to prepare 1,4-skipped diynes with good yields and in mild conditions. We have shown that this reaction also works very well with germanium and tin derivatives as an alternative to silicon. This new method can be useful for the synthesis of polyunsaturated fatty acids.