Details

Autor(en) / Beteiligte

• Tilley, Peter A. G.
• Fox, Julie D.
• Jayaraman, Gayatri C.
• Preiksaitis, Jutta K.

Titel

Nucleic Acid Testing for West Nile Virus RNA in Plasma Enhances Rapid Diagnosis of Acute Infection in Symptomatic Patients

Ist Teil von

• The Journal of infectious diseases, 2006-05, Vol.193 (10), p.1361-1364

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Although nucleic acid amplification testing (NAAT) for West Nile virus (WNV) is useful in screening blood donors, such methods have not been studied in symptomatic patients. For diagnosis of WNV infection, 1.0 mL of plasma was tested by NAAT, and WNV-specific immunoglobulin M was assayed. Of 276 WNV cases, 191 were tested by both serology and NAAT. Of these, 86 (45.0%), 111 (58.1%), and 180 (94.2%) were detected by NAAT, serology, and combined NAAT and serology, respectively. NAAT-based screening was most useful within 8 days of the onset of symptoms. Viremia is common in early symptomatic WNV infection, and NAAT enhances diagnostic yield